Problem:
You’re comparing the differential data during a sync process (migrating to OneDrive for example) and TC shows thousands of useless files like thumbs.db and you want to exclude them.
Solution:
Get to the synchronize data screen and at the top you should see *.* Replace it with the following and add extensions as you see fit:
*.*|thumbs.db;desktop.ini;iconcache.db;.DS_Store